InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lbx1

Summary

InnateDB Protein

IDBP-170728.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lbx1

Protein Name

ladybird homeobox homolog 1 (Drosophila)

Synonyms

Lbx1h;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000096997

InnateDB Gene

IDBG-170726 (Lbx1)

Protein Structure

UniProt Annotation

Function

Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord. {ECO:0000269PubMed:10603359, ECO:0000269PubMed:12062039, ECO:0000269PubMed:16234809}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in the dorsal part of the spinal cord and hindbrain and in presumptive myogenic cells in lateral regions of differentiating somites. {ECO:0000269PubMed:8645601}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001947	heart looping
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007517	muscle organ development
GO:0008285	negative regulation of cell proliferation
GO:0021522	spinal cord motor neuron differentiation
GO:0021920	regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification
GO:0045665	negative regulation of neuron differentiation
GO:0048663	neuron fate commitment
GO:0048664	neuron fate determination