Version 5.4
Mus musculus Gene: Lbx1
Summary
InnateDB Gene IDBG-170726.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lbx1
Gene Name ladybird homeobox homolog 1 (Drosophila)
Synonyms Lbx1h
Species Mus musculus
Ensembl Gene ENSMUSG00000025216
Encoded Proteins
IDBP-170728
ladybird homeobox homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138136:
This gene and the orthologous mouse gene were found by their homology to the Drosophila lady bird early and late homeobox genes. In the mouse, this gene is a key regulator of muscle precursor cell migration and is required for the acquisition of dorsal identities of forelimb muscles. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:45232684-45235812
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000099401 ENSMUSP00000096997
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001947 heart looping
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007517 muscle organ development
GO:0008285 negative regulation of cell proliferation
GO:0021522 spinal cord motor neuron differentiation
GO:0021920 regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification
GO:0045665 negative regulation of neuron differentiation
GO:0048663 neuron fate commitment
GO:0048664 neuron fate determination
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000138136
View Gene Order
ENSBTAG00000002261
Not yet available
Cross-References
SwissProt P52955
TrEMBL
UniProt Splice Variant
Entrez Gene 16814
UniGene Mm.116815
RefSeq NM_010691 XM_006526722
OMIM
CCDS CCDS29859
HPRD
IMGT
MGI ID MGI:104867
MGI Symbol Lbx1
EMBL AB108497 AK144562 BC119177 BC120586 X90829
GenPept AAI19178 AAI20587 BAC75634 BAE25939 CAA62343
RNA Seq Atlas 16814

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca