InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cyp1a2

Summary

InnateDB Protein

IDBP-170748.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyp1a2

Protein Name

cytochrome P450, family 1, subfamily a, polypeptide 2

Synonyms

CP12; Cyp1a1; P450-3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034860

InnateDB Gene

IDBG-170746 (Cyp1a2)

Protein Structure

UniProt Annotation

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0019899	enzyme binding
GO:0020037	heme binding
GO:0032451	demethylase activity
GO:0034875	caffeine oxidase activity
GO:0070330	aromatase activity

Biological Process

GO:0006706	steroid catabolic process
GO:0006725	cellular aromatic compound metabolic process
GO:0006778	porphyrin-containing compound metabolic process
GO:0009403	toxin biosynthetic process
GO:0009404	toxin metabolic process
GO:0009791	post-embryonic development
GO:0009820	alkaloid metabolic process
GO:0010033	response to organic substance
GO:0010468	regulation of gene expression
GO:0014070	response to organic cyclic compound
GO:0016098	monoterpenoid metabolic process
GO:0017144	drug metabolic process
GO:0018894	dibenzo-p-dioxin metabolic process
GO:0030324	lung development
GO:0032355	response to estradiol
GO:0032496	response to lipopolysaccharide
GO:0032787	monocarboxylic acid metabolic process
GO:0035902	response to immobilization stress
GO:0042493	response to drug
GO:0042737	drug catabolic process
GO:0042738	exogenous drug catabolic process
GO:0045333	cellular respiration
GO:0046483	heterocycle metabolic process
GO:0050665	hydrogen peroxide biosynthetic process
GO:0055114	oxidation-reduction process
GO:0070989	oxidative demethylation
GO:0071276	cellular response to cadmium ion
GO:0071615	oxidative deethylation

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:88589

InterPro

IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR002403 Cytochrome P450, E-class, group IV
IPR008066 Cytochrome P450, E-class, group I, CYP1

PFAM

PF00067

PRINTS

PR00385
PR00463
PR00465
PR01683

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P00186