InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Clk3

Summary

InnateDB Protein

IDBP-170846.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Clk3

Protein Name

CDC-like kinase 3

Synonyms

AI256811;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000067341

InnateDB Gene

IDBG-170844 (Clk3)

Protein Structure

UniProt Annotation

Function

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. {ECO:0000269PubMed:9307018}.

Subcellular Localization

Nucleus. Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome.

Disease Associations

Tissue Specificity

Present at high levels in testis and ovary. In testis, expression is restricted to elongated, maturing spermatozoa. Also present in spleen, brain, lung and liver (at protein level). {ECO:0000269PubMed:10585269}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006468	protein phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0043484	regulation of RNA splicing
GO:0046777	protein autophosphorylation

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005634	nucleus
GO:0016020	membrane
GO:0045111	intermediate filament cytoskeleton

Protein Structure and Domains

PDB ID

MGI:1098670

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt