InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Poll

Summary

InnateDB Protein

IDBP-170877.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Poll

Protein Name

polymerase (DNA directed), lambda

Synonyms

1110003P06Rik; AV007317;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026239

InnateDB Gene

IDBG-170875 (Poll)

Protein Structure

UniProt Annotation

Function

Repair polymerase. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003824	catalytic activity
GO:0003887	DNA-directed DNA polymerase activity
GO:0016779	nucleotidyltransferase activity
GO:0016829	lyase activity
GO:0046872	metal ion binding

Biological Process

GO:0006261	DNA-dependent DNA replication
GO:0006287	base-excision repair, gap-filling
GO:0006289	nucleotide-excision repair

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:1889000

InterPro

IPR001357 BRCT domain
IPR002008 DNA polymerase, family X, beta-like
IPR002054 DNA-directed DNA polymerase X
IPR010996 DNA polymerase beta-like, N-terminal domain
IPR018944 DNA polymerase lambda, fingers domain
IPR022312 DNA polymerase family X

PFAM

PF00533
PF12738
PF10391

PRINTS

PR00870
PR00869

PIRSF

SMART

SM00292
SM00483

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt