InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cacnb4

Summary

InnateDB Protein

IDBP-170906.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cacnb4

Protein Name

calcium channel, voltage-dependent, beta 4 subunit

Synonyms

3110038O15Rik; Cchb4; lh;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099822

InnateDB Gene

IDBG-170902 (Cacnb4)

Protein Structure

UniProt Annotation

Function

The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005245	voltage-gated calcium channel activity
GO:0005515	protein binding
GO:0008331	high voltage-gated calcium channel activity
GO:0019901	protein kinase binding

Biological Process

GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0007214	gamma-aminobutyric acid signaling pathway
GO:0007528	neuromuscular junction development
GO:0007628	adult walking behavior
GO:0014051	gamma-aminobutyric acid secretion
GO:0019227	neuronal action potential propagation
GO:0035249	synaptic transmission, glutamatergic
GO:0042391	regulation of membrane potential
GO:0046058	cAMP metabolic process
GO:0048536	spleen development
GO:0048538	thymus development
GO:0048541	Peyer's patch development
GO:0048747	muscle fiber development
GO:0050852	T cell receptor signaling pathway
GO:0050877	neurological system process
GO:0050908	detection of light stimulus involved in visual perception
GO:0070588	calcium ion transmembrane transport
GO:1901385	regulation of voltage-gated calcium channel activity

Cellular Component

GO:0005886	plasma membrane
GO:0005891	voltage-gated calcium channel complex
GO:0045202	synapse

Protein Structure and Domains

PDB ID

MGI:103301

InterPro

IPR000584 Voltage-dependent calcium channel, L-type, beta subunit
IPR001452 SH3 domain
IPR008145 Guanylate kinase/L-type calcium channel beta subunit
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF12052
PF00018
PF14604
PF00625

PRINTS

PR01626
PR00452

PIRSF

SMART

SM00326
SM00072

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt