InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cacnb4

Summary

InnateDB Gene

IDBG-170902.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cacnb4

Gene Name

calcium channel, voltage-dependent, beta 4 subunit

Synonyms

3110038O15Rik; Cchb4; lh

Species

Mus musculus

Ensembl Gene

ENSMUSG00000017412

Encoded Proteins

IDBP-170904

calcium channel, voltage-dependent, beta 4 subunit

IDBP-170906

calcium channel, voltage-dependent, beta 4 subunit

IDBP-170908

calcium channel, voltage-dependent, beta 4 subunit

IDBP-719285

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000182389:
This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:52428320-52676831

Strand

Reverse strand

Band

C1.1

Transcripts

ENSMUST00000078324	ENSMUSP00000077438
ENSMUST00000102761	ENSMUSP00000099822
ENSMUST00000102760	ENSMUSP00000099821
ENSMUST00000132322
ENSMUST00000148837
ENSMUST00000178799	ENSMUSP00000136811

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005245	voltage-gated calcium channel activity
GO:0005515	protein binding
GO:0008331	high voltage-gated calcium channel activity
GO:0019901	protein kinase binding

Biological Process

GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0007214	gamma-aminobutyric acid signaling pathway
GO:0007528	neuromuscular junction development
GO:0007628	adult walking behavior
GO:0014051	gamma-aminobutyric acid secretion
GO:0019227	neuronal action potential propagation
GO:0035249	synaptic transmission, glutamatergic
GO:0042391	regulation of membrane potential
GO:0046058	cAMP metabolic process
GO:0048536	spleen development
GO:0048538	thymus development
GO:0048541	Peyer's patch development
GO:0048747	muscle fiber development
GO:0050852	T cell receptor signaling pathway
GO:0050877	neurological system process
GO:0050908	detection of light stimulus involved in visual perception
GO:0070588	calcium ion transmembrane transport
GO:1901385	regulation of voltage-gated calcium channel activity