InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Xrcc4

Summary

InnateDB Protein

IDBP-171007.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Xrcc4

Protein Name

X-ray repair complementing defective repair in Chinese hamster cells 4

Synonyms

2310057B22Rik; AW413319; AW545101;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022115

InnateDB Gene

IDBG-171005 (Xrcc4)

Protein Structure

UniProt Annotation

Function

Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding

Biological Process

GO:0001701	in utero embryonic development
GO:0002328	pro-B cell differentiation
GO:0006266	DNA ligation
GO:0006302	double-strand break repair
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0006310	DNA recombination
GO:0007417	central nervous system development
GO:0010165	response to X-ray
GO:0010212	response to ionizing radiation
GO:0010332	response to gamma radiation
GO:0033077	T cell differentiation in thymus
GO:0033151	V(D)J recombination
GO:0033152	immunoglobulin V(D)J recombination
GO:0043524	negative regulation of neuron apoptotic process
GO:0045190	isotype switching
GO:0048146	positive regulation of fibroblast proliferation
GO:0050769	positive regulation of neurogenesis
GO:0051103	DNA ligation involved in DNA repair
GO:0051351	positive regulation of ligase activity
GO:0071285	cellular response to lithium ion

Cellular Component

GO:0005634	nucleus
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex
GO:0030054	cell junction
GO:0032807	DNA ligase IV complex
GO:0070419	nonhomologous end joining complex