Mus musculus Protein: Smarca5 | |||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||
InnateDB Protein | IDBP-171024.6 | ||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
Gene Symbol | Smarca5 | ||||||||||||||||||||||||
Protein Name | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 | ||||||||||||||||||||||||
Synonyms | 4933427E24Rik; D030040M08Rik; D330027N15Rik; MommeD4; Snf2h; | ||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000044361 | ||||||||||||||||||||||||
InnateDB Gene | IDBG-171022 (Smarca5) | ||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||||
Function | Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. {ECO:0000269PubMed:11532953, ECO:0000269PubMed:11980720, ECO:0000269PubMed:12198165, ECO:0000269PubMed:12368916, ECO:0000269PubMed:14617767, ECO:0000269PubMed:19092802}. | ||||||||||||||||||||||||
Subcellular Localization | Nucleus {ECO:0000255PROSITE- ProRule:PRU00624, ECO:0000269PubMed:11532953}. | ||||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||||
Tissue Specificity | Ubiquitously expressed. | ||||||||||||||||||||||||
Comments | |||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||||
PDB ID | MGI:1935129 | ||||||||||||||||||||||||
InterPro |
IPR000330
SNF2-related IPR001005 SANT/Myb domain IPR001650 Helicase, C-terminal IPR006935 Helicase/UvrB domain IPR009057 Homeodomain-like IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal IPR014001 Helicase, superfamily 1/2, ATP-binding domain IPR015194 ISWI HAND domain IPR015195 SLIDE domain IPR021006 Histone deacetylase complex, subunit 2/3 IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF00176
PF00249 PF00271 PF04851 PF00270 PF09110 PF09111 PF11496 |
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PRINTS | |||||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||||
SMART |
SM00717
SM00490 SM00487 |
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TIGRFAMs | |||||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||||
Modification | |||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||
SwissProt | Q91ZW3 | ||||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q91ZW3 | ||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||
Entrez Gene | 93762 | ||||||||||||||||||||||||
UniGene | Mm.483622 | ||||||||||||||||||||||||
RefSeq | NP_444354 | ||||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||||
MGI Symbol | Smarca5 | ||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||
CCDS | CCDS22442 | ||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||
EMBL | AF325921 AF375046 AK039811 AK052320 BC021922 BC053069 | ||||||||||||||||||||||||
GenPept | AAH21922 AAH53069 AAK52454 AAL25793 BAC30458 BAC34934 | ||||||||||||||||||||||||