InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Smarca5

Summary

InnateDB Gene

IDBG-171022.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Smarca5

Gene Name

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5

Synonyms

4933427E24Rik; D030040M08Rik; D330027N15Rik; MommeD4; Snf2h

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031715

Encoded Proteins

IDBP-171024

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000153147:
The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:80698507-80739497

Strand

Reverse strand

Band

Transcripts

ENSMUST00000043359	ENSMUSP00000044361
ENSMUST00000122807
ENSMUST00000142470
ENSMUST00000150277
ENSMUST00000140110
ENSMUST00000148455

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	30 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	74 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0016887	ATPase activity
GO:0031491	nucleosome binding
GO:0042393	histone binding

Biological Process

GO:0000183	chromatin silencing at rDNA
GO:0006200	ATP catabolic process
GO:0006302	double-strand break repair
GO:0006333	chromatin assembly or disassembly
GO:0006334	nucleosome assembly
GO:0006338	chromatin remodeling
GO:0006352	DNA-templated transcription, initiation
GO:0016584	nucleosome positioning
GO:0043044	ATP-dependent chromatin remodeling
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0000793	condensed chromosome
GO:0005634	nucleus
GO:0005677	chromatin silencing complex
GO:0005730	nucleolus
GO:0016589	NURF complex
GO:0031010	ISWI-type complex
GO:0031213	RSF complex
GO:0043596	nuclear replication fork