Version 5.4
Mus musculus Protein: Stam2
Summary
InnateDB Protein IDBP-171044.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Stam2
Protein Name signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
Synonyms 1200004O12Rik; 5730456G07Rik; BB145015; Hbp;
Species Mus musculus
Ensembl Protein ENSMUSP00000099820
InnateDB Gene IDBG-171042 (Stam2)
Protein Structure
UniProt Annotation
Function Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:10651905, ECO:0000269PubMed:12551915}. Early endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitously expressed, with highest levels in testis. {ECO:0000269PubMed:10651905}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 36 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006886 intracellular protein transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031901 early endosome membrane
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID MGI:1929100
InterPro IPR001452 SH3 domain
IPR002014 VHS
IPR003903 Ubiquitin interacting motif
IPR008942 ENTH/VHS
IPR011511 Variant SH3 domain
IPR018205 VHS subgroup
PFAM PF00018
PF14604
PF00790
PF02809
PF07653
PRINTS PR00452
PIRSF
SMART SM00326
SM00726
SM00288
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O88811
PhosphoSite PhosphoSite-O88811
TrEMBL Q3TGH8
UniProt Splice Variant
Entrez Gene 56324
UniGene Mm.393555
RefSeq NP_062641
MGI ID 1UJ0
MGI Symbol Stam2
OMIM
CCDS CCDS16037
HPRD
IMGT
EMBL AB012611 AK004604 AK044230 AK159699 AK168729 AL928960 AY902333 BC013818 CH466519 CT978680
GenPept AAH13818 AAX90618 BAA33547 BAB23403 BAC31830 BAE35299 BAE40570 CAM23666 CAX15926 EDL26912

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca