InnateDB Protein
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IDBP-171109.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Vdac1
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Protein Name
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voltage-dependent anion channel 1
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Synonyms
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AL033343; Vdac5;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000099819
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InnateDB Gene
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IDBG-171107 (Vdac1)
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Protein Structure
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Function |
Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. {ECO:0000269PubMed:10716730, ECO:0000269PubMed:15477379, ECO:0000269PubMed:18988731}.
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Subcellular Localization |
Isoform Mt-VDAC1: Mitochondrion outer membrane; Multi-pass membrane protein.Isoform Pl-VDAC1: Cell membrane; Multi-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
High levels of expression detected in heart, kidney, brain, and skeletal muscle. Not expressed in testis. {ECO:0000269PubMed:8660977}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 72 interaction(s) predicted by orthology.
Experimentally validated |
Total |
26
[view]
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Protein-Protein |
26
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
72 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:106919
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InterPro |
IPR001925
Porin, eukaryotic type
IPR027246
Eukaryotic porin/Tom40
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PFAM |
PF01459
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PRINTS |
PR00185
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q60932
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PhosphoSite |
PhosphoSite-Q60932
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
22333
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UniGene |
Mm.3555
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RefSeq |
NP_035824
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MGI ID |
3EMN
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MGI Symbol |
Vdac1
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OMIM |
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CCDS |
CCDS24671
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HPRD |
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IMGT |
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EMBL |
AK168672
AK169160
AK169282
AK169354
AK169671
AL645589
BC092257
U30840
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GenPept |
AAB47777
AAH92257
BAE40522
BAE40939
BAE41040
BAE41103
BAE41292
CAI24939
CAM19812
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