InnateDB Protein
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IDBP-171132.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Pi4kb
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Protein Name
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phosphatidylinositol 4-kinase, catalytic, beta polypeptide
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Synonyms
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ESTM41; PI4K-beta; PI4Kbeta; Pik4cb;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000072134
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InnateDB Gene
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IDBG-171130 (Pi4kb)
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Protein Structure
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Function |
Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation (By similarity). Involved in Golgi-to-plasma membrane trafficking (By similarity). {ECO:0000250}.
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Subcellular Localization |
Endomembrane system {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Rough endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
9 [view]
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Molecular Function |
Accession |
GO Term |
GO:0004430
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1-phosphatidylinositol 4-kinase activity
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GO:0005515
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protein binding
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GO:0005524
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ATP binding
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GO:0016772
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transferase activity, transferring phosphorus-containing groups
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GO:0016773
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phosphotransferase activity, alcohol group as acceptor
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Biological Process |
GO:0006661
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phosphatidylinositol biosynthetic process
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GO:0046854
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phosphatidylinositol phosphorylation
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GO:0048015
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phosphatidylinositol-mediated signaling
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Cellular Component |
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PDB ID |
MGI:1334433
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InterPro |
IPR000403
Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR011009
Protein kinase-like domain
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PFAM |
PF00454
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PRINTS |
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PIRSF |
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SMART |
SM00146
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BKC8
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PhosphoSite |
PhosphoSite-Q8BKC8
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TrEMBL |
D6RI80
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UniProt Splice Variant |
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Entrez Gene |
107650
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UniGene |
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RefSeq |
NP_780565
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MGI ID |
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MGI Symbol |
Pi4kb
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OMIM |
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CCDS |
CCDS17599
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HPRD |
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IMGT |
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EMBL |
AC087062
AK028974
AK053614
AK157918
AK172074
BC079846
BC113176
BC113781
BC138457
BC138458
CH466620
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GenPept |
AAH79846
AAI13177
AAI13782
AAI38458
AAI38459
BAC26222
BAC35448
BAE34263
BAE42812
EDL38762
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