InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gab1

Summary

InnateDB Protein

IDBP-171149.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gab1

Protein Name

growth factor receptor bound protein 2-associated protein 1

Synonyms

AA408973; AW107238;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034150

InnateDB Gene

IDBG-171147 (Gab1)

Protein Structure

UniProt Annotation

Function

Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR) (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0006979	response to oxidative stress
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007257	activation of JUN kinase activity
GO:0007507	heart development
GO:0008544	epidermis development
GO:0030334	regulation of cell migration
GO:0043410	positive regulation of MAPK cascade
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0060711	labyrinthine layer development
GO:0070102	interleukin-6-mediated signaling pathway