Version 5.4
| Mus musculus Gene: Gab1 | |||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||
| InnateDB Gene | IDBG-171147.6 | ||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
| Gene Symbol | Gab1 | ||||||||||||||||||||||||
| Gene Name | growth factor receptor bound protein 2-associated protein 1 | ||||||||||||||||||||||||
| Synonyms | AA408973; AW107238 | ||||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000031714 | ||||||||||||||||||||||||
| Encoded Proteins |
growth factor receptor bound protein 2-associated protein 1
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||||||||||
| Summary |
[Homo sapiens] GAB1 inhibits vesicular stomatitis virus (VSV) replication and VSV infection-induced cell damage by inducing type I IFNs and IFN-inducible gene expression via the PI3K/Akt pathway. It is needed for full activation of TLR3/4- and RIG-I-triggered innate responses by promoting activation of PI3K/Akt, MAPKs, and NF-kappaB pathways.
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| Entrez Gene | |||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109458:
The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] |
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| Gene Information | |||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||
| Genomic Location | Chromosome 8:80764434-80880479 | ||||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||||
| Band | C2 | ||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||
| REACTOME |
Innate Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
PI3K/AKT activation pathway
Disease pathway
Signaling by constitutively active EGFR pathway
Signaling by Insulin receptor pathway
Signaling by FGFR in disease pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
PIP3 activates AKT signaling pathway
Immune System pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
PI3K events in ERBB4 signaling pathway
PI-3K cascade pathway
Signaling by EGFR pathway
Insulin receptor signalling cascade pathway
IRS-related events triggered by IGF1R pathway
IGF1R signaling cascade pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
PI3K Cascade pathway
Fc epsilon receptor (FCERI) signaling pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR mutants pathway
Signalling by NGF pathway
Adaptive Immune System pathway
Signaling by PDGF pathway
GAB1 signalosome pathway
IRS-related events pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-mediated signalling pathway
PI3K events in ERBB2 signaling pathway
Signal Transduction pathway
Signaling by FGFR pathway
Signaling by EGFR in Cancer pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
DAP12 interactions pathway
DAP12 signaling pathway
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| KEGG |
Renal cell carcinoma pathway
ErbB signaling pathway pathway
Neurotrophin signaling pathway pathway
Bacterial invasion of epithelial cells pathway
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| INOH |
FGF signaling pathway pathway
HGF signaling pathway pathway
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| PID NCI | |||||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||
| NETPATH |
Alpha6Beta4Integrin pathway
EGFR1 pathway
TNFalpha pathway
BCR pathway
IL3 pathway
IL6 pathway
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| REACTOME |
PIP3 activates AKT signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
PI3K/AKT activation pathway
GAB1 signalosome pathway
Signaling by EGFR pathway
PI3K events in ERBB4 signaling pathway
Signaling by ERBB4 pathway
PI3K Cascade pathway
Signaling by Insulin receptor pathway
IRS-related events triggered by IGF1R pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
PI3K events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
PI-3K cascade pathway
Signaling by FGFR pathway
Signaling by SCF-KIT pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Signaling by constitutively active EGFR pathway
Signaling by FGFR mutants pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR in disease pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Innate Immune System pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
IRS-mediated signalling pathway
Adaptive Immune System pathway
Immune System pathway
Insulin receptor signalling cascade pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-related events pathway
IGF1R signaling cascade pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Disease pathway
DAP12 interactions pathway
Insulin receptor signalling cascade pathway
Signaling by EGFR pathway
GAB1 signalosome pathway
IRS-related events triggered by IGF1R pathway
Signaling by PDGF pathway
Signaling by ERBB4 pathway
Signaling by FGFR pathway
Signaling by FGFR mutants pathway
IRS-related events pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
PI3K events in ERBB2 signaling pathway
Immune System pathway
IRS-mediated signalling pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
IGF1R signaling cascade pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
Signal Transduction pathway
PI3K Cascade pathway
Signaling by Insulin receptor pathway
Signaling by EGFR in Cancer pathway
PI-3K cascade pathway
NGF signalling via TRKA from the plasma membrane pathway
PI3K events in ERBB4 signaling pathway
Downstream signaling of activated FGFR pathway
Signaling by constitutively active EGFR pathway
Signalling by NGF pathway
PI3K/AKT Signaling in Cancer pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Adaptive Immune System pathway
Downstream signal transduction pathway
PIP3 activates AKT signaling pathway
Signaling by SCF-KIT pathway
Innate Immune System pathway
PI3K/AKT activation pathway
DAP12 signaling pathway
Disease pathway
Signaling by FGFR in disease pathway
Fc epsilon receptor (FCERI) signaling pathway
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| KEGG |
ErbB signaling pathway pathway
Renal cell carcinoma pathway
Neurotrophin signaling pathway pathway
Bacterial invasion of epithelial cells pathway
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| INOH |
FGF signaling pathway pathway
HGF signaling pathway pathway
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| PID NCI |
Trk receptor signaling mediated by PI3K and PLC-gamma
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
LPA receptor mediated events
ErbB1 downstream signaling
EPO signaling pathway
Neurotrophic factor-mediated Trk receptor signaling
FGF signaling pathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
Signaling events mediated by TCPTP
Signaling events mediated by VEGFR1 and VEGFR2
Signaling events regulated by Ret tyrosine kinase
SHP2 signaling
PDGFR-beta signaling pathway
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| Cross-References | |||||||||||||||||||||||||
| SwissProt | Q9QYY0 | ||||||||||||||||||||||||
| TrEMBL | Q505A4 | ||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||
| Entrez Gene | 14388 | ||||||||||||||||||||||||
| UniGene | |||||||||||||||||||||||||
| RefSeq | NM_021356 | ||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||
| CCDS | CCDS22443 | ||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||
| MGI ID | MGI:108088 | ||||||||||||||||||||||||
| MGI Symbol | Gab1 | ||||||||||||||||||||||||
| EMBL | AJ250669 BC007483 BC094659 CH466525 CT010264 | ||||||||||||||||||||||||
| GenPept | AAH07483 AAH94659 CAB59832 CAJ18472 EDL10885 | ||||||||||||||||||||||||
| RNA Seq Atlas | 14388 | ||||||||||||||||||||||||