InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sema7a

Summary

InnateDB Protein

IDBP-171173.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sema7a

Protein Name

sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A

Synonyms

2900057C09Rik; CDw108; H-Sema-L; M-Sema-L; Semal;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000042211

InnateDB Gene

IDBG-171171 (Sema7a)

Protein Structure

UniProt Annotation

Function

Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. {ECO:0000269PubMed:12879062, ECO:0000269PubMed:16713976, ECO:0000269PubMed:17377534}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:17377534}; Lipid-anchor, GPI-anchor {ECO:0000269PubMed:17377534}; Extracellular side {ECO:0000269PubMed:17377534}.

Disease Associations

Tissue Specificity

Highly expressed in activated T-cells (at protein level). Highest expression in brain. Lower in heart, thymus, spleen, testis and ovary. The expression increases in late embryonic and postnatal stages. Detected in T-cells. {ECO:0000269PubMed:16713976, ECO:0000269PubMed:17377534}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005178	integrin binding
GO:0005515	protein binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0001934	positive regulation of protein phosphorylation
GO:0006954	inflammatory response
GO:0007229	integrin-mediated signaling pathway
GO:0007275	multicellular organismal development
GO:0021988	olfactory lobe development
GO:0031175	neuron projection development
GO:0045773	positive regulation of axon extension
GO:0048675	axon extension
GO:0050727	regulation of inflammatory response
GO:0060907	positive regulation of macrophage cytokine production
GO:0070374	positive regulation of ERK1 and ERK2 cascade