InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sema7a

Summary

InnateDB Gene

IDBG-171171.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sema7a

Gene Name

sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A

Synonyms

2900057C09Rik; CDw108; H-Sema-L; M-Sema-L; Semal

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038264

Encoded Proteins

IDBP-171173

sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138623:
The protein encoded by this gene binds to cell surfaces through a glycosylphosphatidylinositol (GPI) linkage. The encoded glycoprotein is found on activated lymphocytes and erythrocytes. This protein may be involved in immunomodulatory and neuronal processes. Defects in this gene can result in loss of bone mineral density (BMD). Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:57940113-57962864

Strand

Forward strand

Band

Transcripts

ENSMUST00000043059

ENSMUSP00000042211

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005178	integrin binding
GO:0005515	protein binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0001934	positive regulation of protein phosphorylation
GO:0006954	inflammatory response
GO:0007229	integrin-mediated signaling pathway
GO:0007275	multicellular organismal development
GO:0021988	olfactory lobe development
GO:0031175	neuron projection development
GO:0045773	positive regulation of axon extension
GO:0048675	axon extension
GO:0050727	regulation of inflammatory response
GO:0060907	positive regulation of macrophage cytokine production
GO:0070374	positive regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0031225	anchored component of membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000138623

View Gene Order

ENSBTAG00000011446

Not yet available

Pathways

NETPATH

REACTOME

REACT_261444

Axon guidance pathway

REACT_188576

Developmental Biology pathway

REACT_263034

Semaphorin interactions pathway

REACT_231928

Other semaphorin interactions pathway

KEGG

mmu04360

Axon guidance pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_19200

Other semaphorin interactions pathway

REACT_111045

Developmental Biology pathway

REACT_19271

Semaphorin interactions pathway

REACT_18266

Axon guidance pathway

KEGG

hsa04360

Axon guidance pathway

INOH

PID NCI

Cross-References

SwissProt

Q9QUR8

TrEMBL

UniProt Splice Variant

Entrez Gene

20361

UniGene

Mm.335187

RefSeq

NM_011352 XM_006510888 XM_006510889

OMIM

CCDS

CCDS23235

HPRD

IMGT

MGI ID

MGI:1306826

MGI Symbol

Sema7a

EMBL

AB017532 AF030699 AF176670 BC057875

GenPept

AAC34262 AAD53118 AAH57875 BAA75665

RNA Seq Atlas

20361