InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prpf40a

Summary

InnateDB Protein

IDBP-171249.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prpf40a

Protein Name

PRP40 pre-mRNA processing factor 40 homolog A (yeast)

Synonyms

2810012K09Rik; FBP11; Fnbp11; Fnbp3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000075655

InnateDB Gene

IDBG-171245 (Prpf40a)

Protein Structure

UniProt Annotation

Function

Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing. {ECO:0000269PubMed:14697212}.

Subcellular Localization

Nucleus speckle. Nucleus matrix. Note=Colocalizes with AKAP8L in the nuclear matrix.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 91 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	91 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0070064	proline-rich region binding

Biological Process

GO:0006397	mRNA processing
GO:0007010	cytoskeleton organization
GO:0008360	regulation of cell shape
GO:0008380	RNA splicing
GO:0016477	cell migration
GO:0032465	regulation of cytokinesis