InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cyp11a1

Summary

InnateDB Protein

IDBP-171266.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyp11a1

Protein Name

cytochrome P450, family 11, subfamily a, polypeptide 1

Synonyms

cscc; Cyp11a; Cypxia1; D9Ertd411e; P450scc; Scc;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034874

InnateDB Gene

IDBG-171264 (Cyp11a1)

Protein Structure

UniProt Annotation

Function

Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone. {ECO:0000250}.

Subcellular Localization

Mitochondrion membrane.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0008386	cholesterol monooxygenase (side-chain-cleaving) activity
GO:0015485	cholesterol binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding

Biological Process

GO:0001101	response to acid
GO:0006082	organic acid metabolic process
GO:0006694	steroid biosynthetic process
GO:0006700	C21-steroid hormone biosynthetic process
GO:0006701	progesterone biosynthetic process
GO:0006703	estrogen biosynthetic process
GO:0007584	response to nutrient
GO:0007617	mating behavior
GO:0008203	cholesterol metabolic process
GO:0008584	male gonad development
GO:0009651	response to salt stress
GO:0010033	response to organic substance
GO:0010212	response to ionizing radiation
GO:0010332	response to gamma radiation
GO:0014037	Schwann cell differentiation
GO:0014070	response to organic cyclic compound
GO:0017085	response to insecticide
GO:0018879	biphenyl metabolic process
GO:0018894	dibenzo-p-dioxin metabolic process
GO:0018958	phenol-containing compound metabolic process
GO:0018963	phthalate metabolic process
GO:0021549	cerebellum development
GO:0021766	hippocampus development
GO:0033197	response to vitamin E
GO:0033327	Leydig cell differentiation
GO:0033591	response to L-ascorbic acid
GO:0033595	response to genistein
GO:0034698	response to gonadotropin
GO:0042493	response to drug
GO:0042542	response to hydrogen peroxide
GO:0043279	response to alkaloid
GO:0043434	response to peptide hormone
GO:0043627	response to estrogen
GO:0044344	cellular response to fibroblast growth factor stimulus
GO:0046677	response to antibiotic
GO:0046686	response to cadmium ion
GO:0048545	response to steroid hormone
GO:0050756	fractalkine metabolic process
GO:0051412	response to corticosterone
GO:0051591	response to cAMP
GO:0055114	oxidation-reduction process
GO:0060014	granulosa cell differentiation
GO:0060135	maternal process involved in female pregnancy
GO:0060992	response to fungicide
GO:0061370	testosterone biosynthetic process
GO:0071222	cellular response to lipopolysaccharide
GO:0071236	cellular response to antibiotic
GO:0071276	cellular response to cadmium ion
GO:0071320	cellular response to cAMP
GO:0071347	cellular response to interleukin-1
GO:0071356	cellular response to tumor necrosis factor
GO:0071371	cellular response to gonadotropin stimulus
GO:0071372	cellular response to follicle-stimulating hormone stimulus
GO:0071375	cellular response to peptide hormone stimulus
GO:0071560	cellular response to transforming growth factor beta stimulus

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0030061	mitochondrial crista
GO:0043204	perikaryon

Protein Structure and Domains

PDB ID

MGI:88582

InterPro

IPR001128 Cytochrome P450
IPR002397 Cytochrome P450, B-class
IPR002399 Cytochrome P450, mitochondrial
IPR002401 Cytochrome P450, E-class, group I
IPR002403 Cytochrome P450, E-class, group IV

PFAM

PF00067

PRINTS

PR00385
PR00359
PR00408
PR00463
PR00465

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9QZ82