InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cyp11a1

Summary

InnateDB Gene

IDBG-171264.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyp11a1

Gene Name

cytochrome P450, family 11, subfamily a, polypeptide 1

Synonyms

cscc; Cyp11a; Cypxia1; D9Ertd411e; P450scc; Scc

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032323

Encoded Proteins

IDBP-171266

cytochrome P450, family 11, subfamily a, polypeptide 1

IDBP-787645

cytochrome P450, family 11, subfamily a, polypeptide 1

IDBP-787651

cytochrome P450, family 11, subfamily a, polypeptide 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140459:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:58006411-58027023

Strand

Forward strand

Band

Transcripts

ENSMUST00000034874	ENSMUSP00000034874
ENSMUST00000188116	ENSMUSP00000140545
ENSMUST00000188944
ENSMUST00000188539	ENSMUSP00000140777

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0008386	cholesterol monooxygenase (side-chain-cleaving) activity
GO:0015485	cholesterol binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding

Biological Process

GO:0001101	response to acid
GO:0006082	organic acid metabolic process
GO:0006694	steroid biosynthetic process
GO:0006700	C21-steroid hormone biosynthetic process
GO:0006701	progesterone biosynthetic process
GO:0006703	estrogen biosynthetic process
GO:0007584	response to nutrient
GO:0007617	mating behavior
GO:0008203	cholesterol metabolic process
GO:0008584	male gonad development
GO:0009651	response to salt stress
GO:0010033	response to organic substance
GO:0010212	response to ionizing radiation
GO:0010332	response to gamma radiation
GO:0014037	Schwann cell differentiation
GO:0014070	response to organic cyclic compound
GO:0017085	response to insecticide
GO:0018879	biphenyl metabolic process
GO:0018894	dibenzo-p-dioxin metabolic process
GO:0018958	phenol-containing compound metabolic process
GO:0018963	phthalate metabolic process
GO:0021549	cerebellum development
GO:0021766	hippocampus development
GO:0033197	response to vitamin E
GO:0033327	Leydig cell differentiation
GO:0033591	response to L-ascorbic acid
GO:0033595	response to genistein
GO:0034698	response to gonadotropin
GO:0042493	response to drug
GO:0042542	response to hydrogen peroxide
GO:0043279	response to alkaloid
GO:0043434	response to peptide hormone
GO:0043627	response to estrogen
GO:0044344	cellular response to fibroblast growth factor stimulus
GO:0046677	response to antibiotic
GO:0046686	response to cadmium ion
GO:0048545	response to steroid hormone
GO:0050756	fractalkine metabolic process
GO:0051412	response to corticosterone
GO:0051591	response to cAMP
GO:0055114	oxidation-reduction process
GO:0060014	granulosa cell differentiation
GO:0060135	maternal process involved in female pregnancy
GO:0060992	response to fungicide
GO:0061370	testosterone biosynthetic process
GO:0071222	cellular response to lipopolysaccharide
GO:0071236	cellular response to antibiotic
GO:0071276	cellular response to cadmium ion
GO:0071320	cellular response to cAMP
GO:0071347	cellular response to interleukin-1
GO:0071356	cellular response to tumor necrosis factor
GO:0071371	cellular response to gonadotropin stimulus
GO:0071372	cellular response to follicle-stimulating hormone stimulus
GO:0071375	cellular response to peptide hormone stimulus
GO:0071560	cellular response to transforming growth factor beta stimulus