Version 5.4
Mus musculus Protein: Cerk
Summary
InnateDB Protein IDBP-171295.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cerk
Protein Name ceramide kinase
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000038203
InnateDB Gene IDBG-171293 (Cerk)
Protein Structure
UniProt Annotation
Function Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity High level expression in heart, brain and testis; low expression in spleen, liver and lung; not detected in skeletal muscle.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0001729 ceramide kinase activity
GO:0003951 NAD+ kinase activity
GO:0004143 diacylglycerol kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006672 ceramide metabolic process
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0046834 lipid phosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2386052
InterPro IPR001206 Diacylglycerol kinase, catalytic domain
PFAM PF00781
PRINTS
PIRSF
SMART SM00046
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K4Q7
PhosphoSite PhosphoSite-
TrEMBL D3Z254
UniProt Splice Variant
Entrez Gene 223753
UniGene Mm.409270
RefSeq NP_663450
MGI ID
MGI Symbol Cerk
OMIM
CCDS CCDS27728
HPRD
IMGT
EMBL AB079067 AC116764 AK042077 AK052269 AK169528 BC094253
GenPept AAH94253 BAC01155 BAC31157 BAC34908 BAE41212

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca