InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppp2r5c

Summary

InnateDB Protein

IDBP-171390.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppp2r5c

Protein Name

protein phosphatase 2, regulatory subunit B (B56), gamma isoform

Synonyms

2610043M05Rik; 2700063L20Rik; AI060890; AW545884; C85228; D12Bwg0916e; mKIAA0044;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000082053

InnateDB Gene

IDBG-171384 (Ppp2r5c)

Protein Structure

UniProt Annotation

Function

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Chromosome, centromere {ECO:0000250}.

Disease Associations

Tissue Specificity

Highest levels in heart, liver and brain. Lower levels in skeletal muscle, spleen, kidney and lung. Isoform 4 is testis-specific. {ECO:0000269PubMed:15051958}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008601	protein phosphatase type 2A regulator activity

Biological Process

GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007165	signal transduction
GO:0008285	negative regulation of cell proliferation
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0050790	regulation of catalytic activity