Version 5.4
Mus musculus Protein: Kcnip2
Summary
InnateDB Protein IDBP-171409.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kcnip2
Protein Name Kv channel-interacting protein 2
Synonyms KChIP2;
Species Mus musculus
Ensembl Protein ENSMUSP00000084215
InnateDB Gene IDBG-171405 (Kcnip2)
Protein Structure
UniProt Annotation
Function Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCNDV3 trafficking to the cell surface (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in brain. Highly expressed in layer IV of the cerebral cortex and in striatum and hippocampus, but expressed at low levels in cerebellum. Also expressed in heart. According to PubMed:11747815 expressed in heart at much higher levels than in brain. {ECO:0000269PubMed:11263977, ECO:0000269PubMed:11747815, ECO:0000269PubMed:15363885}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005244 voltage-gated ion channel activity
GO:0005267 potassium channel activity
GO:0005509 calcium ion binding
Biological Process
GO:0007165 signal transduction
GO:0034765 regulation of ion transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:2135916
InterPro IPR002048 EF-hand domain
IPR019577 SPARC/Testican, calcium-binding domain
PFAM PF00036
PF13202
PF13405
PF10591
PRINTS
PIRSF
SMART SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JJ69
PhosphoSite PhosphoSite-Q9JJ69
TrEMBL Q3YAA4
UniProt Splice Variant
Entrez Gene 80906
UniGene Mm.213204
RefSeq NP_001263287
MGI ID
MGI Symbol Kcnip2
OMIM
CCDS CCDS70955
HPRD
IMGT
EMBL AB044570 AB044571 AF439339 AF439340 AF439341 AJ278535 AJ278536 AJ278537 AY647241 DQ148505
GenPept AAL32044 AAL32045 AAL32046 AAT68467 AAZ77822 BAA96738 BAA96739 CAC82023 CAC82024 CAC82026

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca