Version 5.4
Mus musculus Gene: Kcnip2
Summary
InnateDB Gene IDBG-171405.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kcnip2
Gene Name Kv channel-interacting protein 2
Synonyms KChIP2
Species Mus musculus
Ensembl Gene ENSMUSG00000025221
Encoded Proteins
IDBP-171407
Kv channel-interacting protein 2
IDBP-171409
Kv channel-interacting protein 2
IDBP-171411
Kv channel-interacting protein 2
IDBP-535200
Kv channel-interacting protein 2
IDBP-533321
Kv channel-interacting protein 2
IDBP-532940
Kv channel-interacting protein 2
IDBP-531797
Kv channel-interacting protein 2
IDBP-536441
Kv channel-interacting protein 2
IDBP-538397
Kv channel-interacting protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the voltage-gated potassium channel-interacting protein (KCNIP) family. KCNIP family members are small calcium binding proteins that commonly exhibit unique variation at their N-termini, and which modulate A-type potassium channels. This gene is predominantly expressed in the adult heart, and to a lesser extent in the brain. Disruption of this gene is associated with susceptibility to cardiac arrhythmias and lack of transient outward potassium current in ventricular myocytes, and downregulated expression is associated with cardiac hypertrophy. The encoded protein has also been implicated as a repressor of immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:45791839-45816061
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000026247 ENSMUSP00000026247
ENSMUST00000086993 ENSMUSP00000084215
ENSMUST00000079431 ENSMUSP00000078400
ENSMUST00000111906
ENSMUST00000162528 ENSMUSP00000125142
ENSMUST00000159210 ENSMUSP00000124763
ENSMUST00000159245 ENSMUSP00000124346
ENSMUST00000161886 ENSMUSP00000124482
ENSMUST00000162661 ENSMUSP00000124821
ENSMUST00000159446 ENSMUSP00000125499
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005244 voltage-gated ion channel activity
GO:0005267 potassium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0015459 potassium channel regulator activity
GO:0042802 identical protein binding
GO:0044325 ion channel binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0007165 signal transduction
GO:0034765 regulation of ion transmembrane transport
GO:0045163 clustering of voltage-gated potassium channels
GO:0071435 potassium ion export
GO:0071805 potassium ion transmembrane transport
GO:0086009 membrane repolarization
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000120049
View Gene Order
ENSBTAG00000016343
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 80906
UniGene Mm.213204
RefSeq NM_001276358 NM_030716 NM_145703 NM_145704
OMIM
CCDS CCDS29868 CCDS38004 CCDS50453 CCDS70955
HPRD
IMGT
MGI ID MGI:2135916
MGI Symbol Kcnip2
EMBL
GenPept
RNA Seq Atlas 80906

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca