InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Usp46

Summary

InnateDB Protein

IDBP-171447.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Usp46

Protein Name

ubiquitin specific peptidase 46

Synonyms

1190009E20Rik; 2410018I08Rik; AI451644;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000070554

InnateDB Gene

IDBG-171445 (Usp46)

Protein Structure

UniProt Annotation

Function

Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2. {ECO:0000269PubMed:19465912}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0036459	ubiquitinyl hydrolase activity

Biological Process

GO:0001662	behavioral fear response
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0008343	adult feeding behavior
GO:0016579	protein deubiquitination
GO:0032228	regulation of synaptic transmission, GABAergic
GO:0048149	behavioral response to ethanol
GO:0060013	righting reflex