Version 5.4
Mus musculus Gene: Usp46
Summary
InnateDB Gene IDBG-171445.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Usp46
Gene Name ubiquitin specific peptidase 46
Synonyms 1190009E20Rik; 2410018I08Rik; AI451644
Species Mus musculus
Ensembl Gene ENSMUSG00000054814
Encoded Proteins
IDBP-171447
ubiquitin specific peptidase 46
IDBP-400840
ubiquitin specific peptidase 46
IDBP-533142
ubiquitin specific peptidase 46
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109189:
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:73998463-74068430
Strand Reverse strand
Band C3.3
Transcripts
ENSMUST00000068058 ENSMUSP00000070554
ENSMUST00000119154 ENSMUSP00000114060
ENSMUST00000128750
ENSMUST00000152408
ENSMUST00000150009
ENSMUST00000145016 ENSMUSP00000114395
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0036459 ubiquitinyl hydrolase activity
Biological Process
GO:0001662 behavioral fear response
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0008343 adult feeding behavior
GO:0016579 protein deubiquitination
GO:0032228 regulation of synaptic transmission, GABAergic
GO:0048149 behavioral response to ethanol
GO:0060013 righting reflex
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000109189
View Gene Order
ENSBTAG00000003443
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.473866 Mm.474139 Mm.48795
RefSeq NM_177561 XM_006504268 XM_006504269
OMIM
CCDS CCDS39112
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca