InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Il15

Summary

InnateDB Protein

IDBP-171494.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il15

Protein Name

interleukin 15

Synonyms

AI503618; IL-15;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034148

InnateDB Gene

IDBG-171492 (Il15)

Protein Structure

UniProt Annotation

Function

Cytokine that stimulates the proliferation of T- lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	0
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005126	cytokine receptor binding
GO:0005515	protein binding

Biological Process

GO:0001779	natural killer cell differentiation
GO:0001866	NK T cell proliferation
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007568	aging
GO:0008284	positive regulation of cell proliferation
GO:0014732	skeletal muscle atrophy
GO:0030212	hyaluronan metabolic process
GO:0031667	response to nutrient levels
GO:0032740	positive regulation of interleukin-17 production
GO:0032819	positive regulation of natural killer cell proliferation
GO:0032825	positive regulation of natural killer cell differentiation
GO:0042102	positive regulation of T cell proliferation
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0045062	extrathymic T cell selection
GO:0045087	innate immune response (InnateDB)
GO:0045580	regulation of T cell differentiation
GO:0048469	cell maturation
GO:0048535	lymph node development
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0050691	regulation of defense response to virus by host
GO:0050778	positive regulation of immune response
GO:0071305	cellular response to vitamin D