Version 5.4
Mus musculus Gene: Il15
Summary
InnateDB Gene IDBG-171492.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il15
Gene Name interleukin 15
Synonyms AI503618; IL-15
Species Mus musculus
Ensembl Gene ENSMUSG00000031712
Encoded Proteins
IDBP-171494
interleukin 15
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22084435
Il15 regulates homeostasis and terminal maturation of NKT cells.
PMID 22940097
IL15 secreted by inflammatory monocytes is critical for the differentiation of memory CD8(+) T and NK lymphocytes into antimicrobial effector cells.
PMID 25466888
Cxcr3 expression in innate CD8+ T cells defines protective antibacterial and cancer immunity upon Il15 stimulation.
InnateDB Annotation from Orthologs
Summary
PMID 20026737
[Homo sapiens] IL15 is a pluripotent anti-apoptotic cytokine that signals to cells of both the innate and adaptive immune system and is regarded as a highly promising immunomodulatory agent in cancer therapy. IL15 prevents two immunopathologic hallmarks of sepsis, namely, apoptosis and immunosuppression, and improves survival in two different models of sepsis.
PMID 22084435
[Homo sapiens] IL15 regulates homeostasis and terminal maturation of NKT cells. (Demonstrated in mice)
PMID 22940097
[Homo sapiens] IL15 secreted by inflammatory monocytes is critical for the differentiation of memory CD8(+) T and NK lymphocytes into antimicrobial effector cells. (Demonstrated in mice)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164136:
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011]
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other\'s activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:82331637-82403222
Strand Reverse strand
Band C2
Transcripts
ENSMUST00000034148 ENSMUSP00000034148
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 0
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005515 protein binding
Biological Process
GO:0001779 natural killer cell differentiation
GO:0001866 NK T cell proliferation
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007568 aging
GO:0008284 positive regulation of cell proliferation
GO:0014732 skeletal muscle atrophy
GO:0030212 hyaluronan metabolic process
GO:0031667 response to nutrient levels
GO:0032740 positive regulation of interleukin-17 production
GO:0032819 positive regulation of natural killer cell proliferation
GO:0032825 positive regulation of natural killer cell differentiation
GO:0042102 positive regulation of T cell proliferation
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0045062 extrathymic T cell selection
GO:0045087 innate immune response (InnateDB)
GO:0045580 regulation of T cell differentiation
GO:0048469 cell maturation
GO:0048535 lymph node development
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050691 regulation of defense response to virus by host
GO:0050778 positive regulation of immune response
GO:0071305 cellular response to vitamin D
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0009986 cell surface
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000164136
View Gene Order
ENSBTAG00000018200
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04630
Jak-STAT signaling pathway pathway
mmu04672
Intestinal immune network for IgA production pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
GPCR signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_14
IL2 pathway
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa04672
Intestinal immune network for IgA production pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt P48346
TrEMBL Q1AHQ6 Q1AHQ7 Q3U1Z6
UniProt Splice Variant
Entrez Gene 16168
UniGene Mm.4392
RefSeq NM_001254747 NM_008357 XM_006530705 XM_006530706 XM_006530707 XM_006530708 XM_006530709 XM_006530710 XM_006530711 XM_006530712 XM_006530713
OMIM
CCDS CCDS40401
HPRD
IMGT
MGI ID MGI:103014
MGI Symbol Il15
EMBL AK155616 BC023698 CH466525 DQ083236 DQ083237 U14332
GenPept AAA75377 AAH23698 AAZ30727 AAZ30728 BAE33347 EDL10892
RNA Seq Atlas 16168

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca