InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dio1

Summary

InnateDB Protein

IDBP-171510.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dio1

Protein Name

deiodinase, iodothyronine, type I

Synonyms

5DI; D1; ITDI1; TXDI1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000081007

InnateDB Gene

IDBG-171508 (Dio1)

Protein Structure

UniProt Annotation

Function

Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004800	thyroxine 5'-deiodinase activity
GO:0008430	selenium binding

Biological Process

GO:0042446	hormone biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:94896

InterPro

IPR000643 Iodothyronine deiodinase
IPR012336 Thioredoxin-like fold

PFAM

PF00837
PF13098
PF13192
PF13462
PF13905

PRINTS

PIRSF

PIRSF001330

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61153

PhosphoSite

PhosphoSite-Q61153

TrEMBL

D6RDQ6

UniProt Splice Variant

Entrez Gene

13370

UniGene

Mm.148342

RefSeq

NP_031886

MGI ID

MGI Symbol

Dio1

OMIM

CCDS

CCDS18436

HPRD

IMGT

EMBL

AL645723 BC019786 BC089608 U49861

GenPept

AAB00228 AAH19786 AAH89608