Version 5.4
| Mus musculus Gene: Dio1 | |||||||
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| Summary | |||||||
| InnateDB Gene | IDBG-171508.6 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | Dio1 | ||||||
| Gene Name | deiodinase, iodothyronine, type I | ||||||
| Synonyms | 5DI; D1; ITDI1; TXDI1 | ||||||
| Species | Mus musculus | ||||||
| Ensembl Gene | ENSMUSG00000034785 | ||||||
| Encoded Proteins |
deiodinase, iodothyronine, type I
deiodinase, iodothyronine, type I
deiodinase, iodothyronine, type I
deiodinase, iodothyronine, type I
deiodinase, iodothyronine, type I
deiodinase, iodothyronine, type I
deiodinase, iodothyronine, type I
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| Protein Structure | |||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||
| Entrez Gene | |||||||
| Summary |
The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3\',5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD). This protein contains a selenocysteine (Sec) residue, which is necessary for maximal enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3\' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Impaired expression of this gene results in hypothyroidism, which causes severe defects in the development of many different tissues. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||
| Type | Protein coding | ||||||
| Genomic Location | Chromosome 4:107291465-107307169 | ||||||
| Strand | Reverse strand | ||||||
| Band | C7 | ||||||
| Transcripts | |||||||
| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||
| NETPATH | |||||||
| REACTOME |
Metabolism pathway
Metabolism of amino acids and derivatives pathway
Regulation of thyroid hormone activity pathway
Thyroxine biosynthesis pathway
Amine-derived hormones pathway
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| KEGG | |||||||
| INOH | |||||||
| PID NCI | |||||||
| Pathway Predictions based on Human Orthology Data | |||||||
| NETPATH | |||||||
| REACTOME |
Thyroxine biosynthesis pathway
Amine-derived hormones pathway
Metabolism of amino acids and derivatives pathway
Regulation of thyroid hormone activity pathway
Metabolism pathway
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| KEGG | |||||||
| INOH | |||||||
| PID NCI | |||||||
| Cross-References | |||||||
| SwissProt | |||||||
| TrEMBL | |||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | |||||||
| UniGene | Mm.148342 | ||||||
| RefSeq | NM_007860 | ||||||
| OMIM | |||||||
| CCDS | CCDS18436 | ||||||
| HPRD | |||||||
| IMGT | |||||||
| MGI ID | |||||||
| MGI Symbol | |||||||
| EMBL | |||||||
| GenPept | |||||||
| RNA Seq Atlas | |||||||