Homo sapiens Protein: NOMO2
Summary
InnateDB Protein IDBP-17152.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOMO2
Protein Name NODAL modulator 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000370883
InnateDB Gene IDBG-17148 (NOMO2)
Protein Structure
UniProt Annotation
Function May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN. {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:15257293, ECO:0000269PubMed:17261586}; Single-pass membrane protein {ECO:0000269PubMed:15257293, ECO:0000269PubMed:17261586}.
Disease Associations
Tissue Specificity Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart. {ECO:0000269PubMed:15257293}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030246 carbohydrate binding
Biological Process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR008969 Carboxypeptidase-like, regulatory domain
IPR008970 Collagen-binding surface protein Cna, B-type domain
IPR013784 Carbohydrate-binding-like fold
IPR019008 Domain of unknown function DUF2012
PFAM PF09430
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5JPE7
PhosphoSite PhosphoSite-Q5JPE7
TrEMBL
UniProt Splice Variant
Entrez Gene 283820
UniGene Hs.595893
RefSeq XP_006710314
HUGO HGNC:22652
OMIM 609158
CCDS
HPRD 12375
IMGT
EMBL AC126755 AC136618 AL832855 BC028389 BC041131
GenPept AAH28389 AAH41131 CAI46162