Version 5.4
Homo sapiens Protein: CLEC4D
Summary
InnateDB Protein IDBP-17161.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLEC4D
Protein Name C-type lectin domain family 4, member D
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000299665
InnateDB Gene IDBG-17159 (CLEC4D)
Protein Structure
UniProt Annotation
Function Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T cells. {ECO:0000269PubMed:14971047}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed weakly in peripheral blood leukocytes, bone marrow and spleen. Expression is confined mostly in monocytes and macrophage and seems to be up-regulated by IL-6, IL-10, TNF-alpha and IFN-gamma. {ECO:0000269PubMed:14971047}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0030246 carbohydrate binding
Biological Process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001304 C-type lectin
IPR002353 Type-2 ice-structuring protein
IPR016187 C-type lectin fold
PFAM PF00059
PRINTS PR00356
PIRSF
SMART SM00034
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WXI8
PhosphoSite PhosphoSite-
TrEMBL A6NHA5
UniProt Splice Variant
Entrez Gene 338339
UniGene Hs.351811
RefSeq NP_525126
HUGO HGNC:14554
OMIM 609964
CCDS CCDS8593
HPRD 13074
IMGT
EMBL AC092746 AF411850 AY115592 AY297446 AY486482 AY486483 BC032313
GenPept AAH32313 AAL37713 AAM75389 AAQ63173 AAS59161 AAS59162

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca