InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mag

Summary

InnateDB Protein

IDBP-171674.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mag

Protein Name

myelin-associated glycoprotein

Synonyms

Gma; siglec-4a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000041464

InnateDB Gene

IDBG-171670 (Mag)

Protein Structure

UniProt Annotation

Function

Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3- linked sialic acid. Isoform L-MAG is critical for the formation of myelin in the CNS, whereas isoform S-MAG is sufficient to maintain the integrity of myelin in PNS. {ECO:0000269PubMed:10625334}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed by myelinating glial cells in the central and peripheral nervous system. Detected in oligodendrocyte processes before formation of compact myelin. Restricted to the periaxonal space after myelination. Isoform S-MAG is the predominant isoform in CNS and PNS of the adult. {ECO:0000269PubMed:10625334, ECO:0000269PubMed:1716323}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007155

cell adhesion

Cellular Component

GO:0016021	integral component of membrane
GO:0033270	paranode region of axon
GO:0043209	myelin sheath
GO:0043220	Schmidt-Lanterman incisure

Protein Structure and Domains

PDB ID

MGI:96912

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07679
PF00047
PF08205

PRINTS

PIRSF

SMART

SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P20917