InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lnx1

Summary

InnateDB Protein

IDBP-171748.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lnx1

Protein Name

ligand of numb-protein X 1

Synonyms

Lnx;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000084405

InnateDB Gene

IDBG-171744 (Lnx1)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65.Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Isoform 1 and isoform 2 are expressed in the heart. Isoform 1 is also expressed in kidney, lung and skeletal muscle while isoform 2 is also expressed in brain. {ECO:0000269PubMed:9535908}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 136 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	136 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0030165	PDZ domain binding
GO:0046872	metal ion binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051260	protein homooligomerization