InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lnx1

Summary

InnateDB Gene

IDBG-171744.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lnx1

Gene Name

ligand of numb-protein X 1

Synonyms

Lnx

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029228

Encoded Proteins

IDBP-171746

ligand of numb-protein X 1

IDBP-171748

ligand of numb-protein X 1

IDBP-253678

ligand of numb-protein X 1

IDBP-400824

ligand of numb-protein X 1

IDBP-400822

ligand of numb-protein X 1

IDBP-400821

ligand of numb-protein X 1

IDBP-534495

ligand of numb-protein X 1

IDBP-541370

ligand of numb-protein X 1

IDBP-541035

ligand of numb-protein X 1

IDBP-539682

ligand of numb-protein X 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000072201:
This gene encodes a membrane-bound protein that is involved in signal transduction and protein interactions. The encoded product is an E3 ubiquitin-protein ligase, which mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. This protein may play an important role in tumorogenesis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene, which is located on chromosome 17, has been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:74592446-74702911

Strand

Reverse strand

Band

C3.3

Transcripts

ENSMUST00000039744	ENSMUSP00000040098
ENSMUST00000087161	ENSMUSP00000084405
ENSMUST00000113531	ENSMUSP00000109159
ENSMUST00000117388	ENSMUSP00000113035
ENSMUST00000117525	ENSMUSP00000113837
ENSMUST00000121690	ENSMUSP00000113565
ENSMUST00000127396	ENSMUSP00000120886
ENSMUST00000154928	ENSMUSP00000117021
ENSMUST00000140084	ENSMUSP00000117935
ENSMUST00000153543	ENSMUSP00000121094

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 136 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	136 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0030165	PDZ domain binding
GO:0046872	metal ion binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051260	protein homooligomerization

Cellular Component

GO:0005737

cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000072201

View Gene Order

ENSBTAG00000020658

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

notch_pathway

Notch signaling pathway

Cross-References

SwissProt

O70263

TrEMBL

A4QPD4 D3YTM4 E9Q4N3

UniProt Splice Variant

Entrez Gene

16924

UniGene

RefSeq

NM_010727 NM_001159577 NM_001159578 NM_001159579 NM_001159580 XM_006504254 XM_006504256 XM_006504257 XM_006504260

OMIM

CCDS

CCDS19347 CCDS51522 CCDS51523 CCDS51524

HPRD

IMGT

MGI ID

MGI:1278335

MGI Symbol

Lnx1

EMBL

AC120865 AC164523 AF034745 AF034746 AK044127 BC040367 BC139771 CH466524

GenPept

AAC40075 AAC40076 AAH40367 AAI39772 BAC31789 EDL37875

RNA Seq Atlas

16924