InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hamp

Summary

InnateDB Protein

IDBP-171777.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hamp

Protein Name

hepcidin antimicrobial peptide

Synonyms

Hamp1; Hepc; Hepc1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000055404

InnateDB Gene

IDBG-171775 (Hamp)

Protein Structure

UniProt Annotation

Function

Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes. {ECO:0000269PubMed:11447267, ECO:0000269PubMed:24880340}.

Subcellular Localization

Secreted {ECO:0000269PubMed:11113132}.

Disease Associations

Tissue Specificity

Highly expressed in the liver and to a much lesser extent in the heart. {ECO:0000269PubMed:11113132, ECO:0000269PubMed:12729891}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	0
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity

Biological Process

GO:0006879	cellular iron ion homeostasis
GO:0042742	defense response to bacterium
GO:0045087	innate immune response (InnateDB)
GO:0050832	defense response to fungus

Cellular Component

GO:0005576

extracellular region

Protein Structure and Domains

PDB ID

MGI:1933533

InterPro

IPR010500 Hepcidin

PFAM

PF06446

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9EQ21

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

84506

UniGene

RefSeq

NP_115930

MGI ID

MGI Symbol

Hamp

OMIM

CCDS

CCDS39895

HPRD

IMGT

EMBL

AF297664 AF503444 BC021587

GenPept

AAG49293 AAH21587 AAM27440