InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hamp

Summary

InnateDB Gene

IDBG-171775.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hamp

Gene Name

hepcidin antimicrobial peptide

Synonyms

Hamp1; Hepc; Hepc1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000050440

Encoded Proteins

IDBP-171777

hepcidin antimicrobial peptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20530874

Hamp is a peptide hormone that regulates iron homeostasis and acts as an antimicrobial peptide, functioning in modulating acute inflammatory responses by mediating transcriptional changes.

PMID 21572427

Hamp (hepcidin), an iron regulatory hormone, inhibits the liver-stage infection in malarial parasitemia by arresting Plasmodium sporozoites in liver hepatocytes and prevents their development into blood-stage parasites.

PMID 21685415

Hamp expression in LPS or Tnfa-stimulated peripheral blood leukocytes is dependent on the NFkB signalling pathway. (Demonstrated in human)

PMID 22544439

Hamp expression is induced by Tlr2/Tlr4 ligands and may regulate pro-inflammatory cytokine production through maintenance of iron homeostasis in macrophages.

InnateDB Annotation from Orthologs

Summary

PMID 21572427

[Homo sapiens] HAMP (hepcidin), an iron regulatory hormone and antimicrobial peptide, inhibits the liver-stage infection in malarial parasitemia by arresting Plasmodium sporozoites in liver hepatocytes and prevents their development into blood-stage parasites. (Demonstrated in murine model)

PMID 21685415

[Homo sapiens] HAMP expression in LPS or TNFA-stimulated peripheral blood leukocytes is dependent on the NFkB signalling pathway.

PMID 22544439

[Homo sapiens] HAMP expression is induced by TLR2/TLR4 ligands and may regulate pro-inflammatory cytokine production through maintenance of iron homeostasis in macrophages. (Demonstrated in mice)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105697:
The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:30942371-30944017

Strand

Reverse strand

Band

Transcripts

ENSMUST00000062620

ENSMUSP00000055404

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	0
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity

Biological Process

GO:0006879	cellular iron ion homeostasis
GO:0042742	defense response to bacterium
GO:0045087	innate immune response (InnateDB)
GO:0050832	defense response to fungus

Cellular Component

GO:0005576

extracellular region

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000105697

View Gene Order

ENSBTAG00000017042

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_032541

OMIM

CCDS

CCDS39895

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas