InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OSBPL1A

Summary

InnateDB Protein

IDBP-1718.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OSBPL1A

Protein Name

oxysterol binding protein-like 1A

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000320291

InnateDB Gene

IDBG-1716 (OSBPL1A)

Protein Structure

UniProt Annotation

Function

Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A. {ECO:0000250, ECO:0000269PubMed:16176980}.

Subcellular Localization

Late endosome {ECO:0000269PubMed:16176980}. Note=Colocalizes with RAB7A, RAB9A and LAMP1 in late endosomes.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0015485	cholesterol binding

Biological Process

GO:0006869	lipid transport
GO:0008203	cholesterol metabolic process
GO:0016192	vesicle-mediated transport
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005770	late endosome
GO:0070062	extracellular vesicular exosome