Version 5.4
Homo sapiens Gene: OSBPL1A
Summary
InnateDB Gene IDBG-1716.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OSBPL1A
Gene Name oxysterol binding protein-like 1A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000141447
Encoded Proteins
IDBP-1718
oxysterol binding protein-like 1A
IDBP-1720
oxysterol binding protein-like 1A
IDBP-230574
oxysterol binding protein-like 1A
IDBP-230576
oxysterol binding protein-like 1A
IDBP-728111
IDBP-726019
IDBP-728042
IDBP-725983
IDBP-727947
IDBP-727500
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist; they encode different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:24162044-24397880
Strand Reverse strand
Band q11.2
Transcripts
ENST00000319481 ENSP00000320291
ENST00000357041 ENSP00000349545
ENST00000399443 ENSP00000382372
ENST00000399441 ENSP00000382370
ENST00000578091 ENSP00000462887
ENST00000579851 ENSP00000463452
ENST00000578013 ENSP00000464617
ENST00000578055 ENSP00000462155
ENST00000579764
ENST00000584119 ENSP00000464541
ENST00000585247
ENST00000581043
ENST00000582350
ENST00000581343
ENST00000582645 ENSP00000462477
ENST00000582618
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0015485 cholesterol binding
Biological Process
GO:0006869 lipid transport
GO:0008203 cholesterol metabolic process
GO:0016192 vesicle-mediated transport
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005770 late endosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000044252
View Gene Order
ENSBTAG00000023259
Not yet available
Pathways
NETPATH
REACTOME
REACT_121399
MHC class II antigen presentation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.370725 Hs.602883 Hs.736788
RefSeq NM_001242508 NM_018030 NM_080597 XM_006722380
HUGO
OMIM
CCDS CCDS11884 CCDS11885 CCDS56056
HPRD 09472
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca