InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hsp90aa1

Summary

InnateDB Protein

IDBP-172057.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hsp90aa1

Protein Name

heat shock protein 90, alpha (cytosolic), class A member 1

Synonyms

86kDa; 89kDa; AL024080; AL024147; hsp4; Hsp86-1; Hsp89; Hsp90; Hspca;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021698

InnateDB Gene

IDBG-172055 (Hsp90aa1)

Protein Structure

UniProt Annotation

Function

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11751894}. Melanosome {ECO:0000250}. Cell membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 693 interaction(s) predicted by orthology.

Experimentally validated
Total	53 [view]
Protein-Protein	53 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	693 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0030235	nitric-oxide synthase regulator activity
GO:0030911	TPR domain binding
GO:0042803	protein homodimerization activity
GO:0051082	unfolded protein binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006457	protein folding
GO:0006809	nitric oxide biosynthetic process
GO:0006950	response to stress
GO:0006986	response to unfolded protein
GO:0042026	protein refolding
GO:0045040	protein import into mitochondrial outer membrane
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0045585	positive regulation of cytotoxic T cell differentiation
GO:0050790	regulation of catalytic activity
GO:0051131	chaperone-mediated protein complex assembly

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0042470	melanosome

Protein Structure and Domains

PDB ID

MGI:96250

InterPro

IPR001404 Heat shock protein Hsp90 family
IPR003594 Histidine kinase-like ATPase, ATP-binding domain
IPR020568 Ribosomal protein S5 domain 2-type fold
IPR020575 Heat shock protein Hsp90, N-terminal

PFAM

PF00183
PF02518
PF13581

PRINTS

PR00775

PIRSF

PIRSF002583

SMART

SM00387

TIGRFAMs

Post-translational Modifications

Modification

Cross-References