Version 5.4
Mus musculus Gene: Hsp90aa1
Summary
InnateDB Gene IDBG-172055.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hsp90aa1
Gene Name heat shock protein 90, alpha (cytosolic), class A member 1
Synonyms 86kDa; 89kDa; AL024080; AL024147; hsp4; Hsp86-1; Hsp89; Hsp90; Hspca
Species Mus musculus
Ensembl Gene ENSMUSG00000021270
Encoded Proteins
IDBP-172057
heat shock protein 90, alpha (cytosolic), class A member 1
IDBP-188621
heat shock protein 90, alpha (cytosolic), class A member 1
IDBP-542900
heat shock protein 90, alpha (cytosolic), class A member 1
IDBP-542904
heat shock protein 90, alpha (cytosolic), class A member 1
IDBP-542906
heat shock protein 90, alpha (cytosolic), class A member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 17420470
[Homo sapiens] HSP90AA1 (HSP90) positively regulates NOD1 activation.
PMID 18950863
[Homo sapiens] HSP90AA1 regulates the stability of transforming growth factor beta-activated kinase 1 (TAK1) in interleukin-1beta (IL1B)-induced cell signalling and IL1B-induced signalling by interacting with and maintaining the stability of TAK1, suggesting that HSP90AA1 might act as the chaperone of TAK1 in immune and inflammatory responses related with IL1A (IL-1) signal cascades.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000080824:
The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:110690605-110702728
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000021698 ENSMUSP00000021698
ENSMUST00000094361 ENSMUSP00000091921
ENSMUST00000129005
ENSMUST00000134967
ENSMUST00000145255
ENSMUST00000155242 ENSMUSP00000118189
ENSMUST00000124156 ENSMUSP00000121138
ENSMUST00000149189 ENSMUSP00000114201
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 693 interaction(s) predicted by orthology.
Experimentally validated
Total 53 [view]
Protein-Protein 53 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 693 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0023026 MHC class II protein complex binding
GO:0030235 nitric-oxide synthase regulator activity
GO:0030911 TPR domain binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0044822 poly(A) RNA binding
GO:0051082 unfolded protein binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006457 protein folding
GO:0006809 nitric oxide biosynthetic process
GO:0006950 response to stress
GO:0006986 response to unfolded protein
GO:0042026 protein refolding
GO:0045040 protein import into mitochondrial outer membrane
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045585 positive regulation of cytotoxic T cell differentiation
GO:0050790 regulation of catalytic activity
GO:0051131 chaperone-mediated protein complex assembly
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0042470 melanosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000080824
View Gene Order
ENSBTAG00000006270
Not yet available
Pathways
NETPATH
REACTOME
REACT_199047
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
REACT_245720
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_239142
Innate Immune System pathway
REACT_198374
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_240530
G2/M Transition pathway
REACT_188191
Signaling by ERBB2 pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_189085
Disease pathway
REACT_199123
Signaling by constitutively active EGFR pathway
REACT_204801
eNOS activation and regulation pathway
REACT_243078
Loss of Nlp from mitotic centrosomes pathway
REACT_221264
eNOS activation pathway
REACT_188957
Cellular responses to stress pathway
REACT_227951
Signaling by VEGF pathway
REACT_243939
EPHA-mediated growth cone collapse pathway
REACT_254306
Sema3A PAK dependent Axon repulsion pathway
REACT_188804
Cell Cycle pathway
REACT_188937
Metabolism pathway
REACT_230745
Immune System pathway
REACT_196573
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_213550
HSF1-dependent transactivation pathway
REACT_246508
Mitotic G2-G2/M phases pathway
REACT_224790
Cellular response to heat stress pathway
REACT_258158
EPH-Ephrin signaling pathway
REACT_244487
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
REACT_261840
VEGFR2 mediated vascular permeability pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_261444
Axon guidance pathway
REACT_223784
Attenuation phase pathway
REACT_196635
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_209368
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_225256
HSF1 activation pathway
REACT_188576
Developmental Biology pathway
REACT_196603
Scavenging by Class F Receptors pathway
REACT_208364
Metabolism of nitric oxide pathway
REACT_263034
Semaphorin interactions pathway
REACT_188257
Signal Transduction pathway
REACT_188180
Signaling by EGFR in Cancer pathway
REACT_253753
Centrosome maturation pathway
KEGG
mmu04612
Antigen processing and presentation pathway
mmu05215
Prostate cancer pathway
mmu05200
Pathways in cancer pathway
mmu04914
Progesterone-mediated oocyte maturation pathway
mmu04621
NOD-like receptor signaling pathway pathway
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_9
TNFalpha pathway
NetPath_14
IL2 pathway
NetPath_18
IL6 pathway
NetPath_21
RANKL pathway
NetPath_24
TSLP pathway
REACTOME
REACT_160315
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_15364
Loss of Nlp from mitotic centrosomes pathway
REACT_15451
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
REACT_15296
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_111176
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
REACT_12477
eNOS activation pathway
REACT_115852
Signaling by constitutively active EGFR pathway
REACT_9434
vRNP Assembly pathway
REACT_19236
Sema3A PAK dependent Axon repulsion pathway
REACT_120956
Cellular responses to stress pathway
REACT_111045
Developmental Biology pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_6167
Influenza Infection pathway
REACT_19271
Semaphorin interactions pathway
REACT_12389
eNOS activation and regulation pathway
REACT_163813
Scavenging by Class F Receptors pathway
REACT_12529
Signaling by VEGF pathway
REACT_6802
Innate Immune System pathway
REACT_200624
Attenuation phase pathway
REACT_12508
Metabolism of nitric oxide pathway
REACT_228016
VEGFR2 mediated vascular permeability pathway
REACT_18266
Axon guidance pathway
REACT_6152
Influenza Viral RNA Transcription and Replication pathway
REACT_160300
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_111102
Signal Transduction pathway
REACT_115566
Cell Cycle pathway
REACT_6900
Immune System pathway
REACT_228063
EPHA-mediated growth cone collapse pathway
REACT_15479
Centrosome maturation pathway
REACT_200775
HSF1-dependent transactivation pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_2203
G2/M Transition pathway
REACT_200819
Cellular response to heat stress pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_6145
Influenza Life Cycle pathway
REACT_21391
Mitotic G2-G2/M phases pathway
REACT_111217
Metabolism pathway
REACT_200744
HSF1 activation pathway
REACT_116125
Disease pathway
REACT_223914
G2/M Transition pathway
REACT_231337
EPHA-mediated growth cone collapse pathway
REACT_205580
HSF1-dependent transactivation pathway
REACT_215545
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_217977
eNOS activation pathway
REACT_226352
eNOS activation and regulation pathway
REACT_220341
Metabolism of nitric oxide pathway
REACT_206069
Cellular responses to stress pathway
REACT_246299
VEGFA-VEGFR2 Pathway pathway
REACT_211617
Scavenging by Class F Receptors pathway
REACT_213138
Immune System pathway
REACT_215505
Cell Cycle, Mitotic pathway
REACT_205006
Loss of Nlp from mitotic centrosomes pathway
REACT_217933
Mitotic G2-G2/M phases pathway
REACT_248222
EPH-Ephrin signaling pathway
REACT_218958
Signaling by ERBB2 pathway
REACT_214934
Cell Cycle pathway
REACT_214353
Signal Transduction pathway
REACT_236208
VEGFR2 mediated vascular permeability pathway
REACT_217273
HSF1 activation pathway
REACT_221368
Signaling by EGFR in Cancer pathway
REACT_211475
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_214350
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
REACT_203140
Axon guidance pathway
REACT_213817
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_203011
Signaling by constitutively active EGFR pathway
REACT_219139
Metabolism pathway
REACT_226693
Signaling by VEGF pathway
REACT_225257
Cellular response to heat stress pathway
REACT_217517
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
REACT_224118
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_215812
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_210400
Centrosome maturation pathway
REACT_213591
Attenuation phase pathway
REACT_216714
Innate Immune System pathway
REACT_207087
Disease pathway
REACT_221457
Semaphorin interactions pathway
REACT_220844
Developmental Biology pathway
REACT_205196
Sema3A PAK dependent Axon repulsion pathway
KEGG
hsa04612
Antigen processing and presentation pathway
hsa05215
Prostate cancer pathway
hsa05200
Pathways in cancer pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa04621
NOD-like receptor signaling pathway pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
pi3kcipathway
Class I PI3K signaling events
pi3kciaktpathway
Class I PI3K signaling events mediated by Akt
avb3_integrin_pathway
Integrins in angiogenesis
myc_activpathway
Validated targets of C-MYC transcriptional activation
lkb1_pathway
LKB1 signaling events
ilk_pathway
Integrin-linked kinase signaling
reg_gr_pathway
Glucocorticoid receptor regulatory network
hdac_classii_pathway
Signaling events mediated by HDAC Class II
erbb_network_pathway
ErbB receptor signaling network
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
hif1apathway
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
ar_tf_pathway
Regulation of Androgen receptor activity
vegfr1_pathway
VEGFR1 specific signals
il2_pi3kpathway
IL2 signaling events mediated by PI3K
telomerasepathway
Regulation of Telomerase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.341186 Mm.398379 Mm.399373 Mm.400443 Mm.424044 Mm.465441 Mm.474664
RefSeq NM_010480 XM_006515485
OMIM
CCDS CCDS26172
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca