InnateDB Protein
|
IDBP-172201.6
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Last Modified
|
2014-10-13 [Report errors or provide feedback]
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Gene Symbol
|
Il5
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Protein Name
|
interleukin 5
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Synonyms
|
Il-5;
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Species
|
Mus musculus
|
Ensembl Protein
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ENSMUSP00000043369
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InnateDB Gene
|
IDBG-172199 (Il5)
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Protein Structure
|
|
Function |
Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
|
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
|
Protein-Protein |
0
|
Protein-DNA |
5
[view]
|
Protein-RNA |
0
|
DNA-DNA |
1
[view]
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
5 [view]
|
|
|
Molecular Function |
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Biological Process |
GO:0006954
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inflammatory response
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GO:0006955
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immune response
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GO:0008284
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positive regulation of cell proliferation
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GO:0019221
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cytokine-mediated signaling pathway
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GO:0030890
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positive regulation of B cell proliferation
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GO:0045087
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innate immune response (InnateDB)
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GO:0045645
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positive regulation of eosinophil differentiation
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0046427
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positive regulation of JAK-STAT cascade
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GO:0050731
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positive regulation of peptidyl-tyrosine phosphorylation
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GO:0051024
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positive regulation of immunoglobulin secretion
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GO:0051091
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positive regulation of sequence-specific DNA binding transcription factor activity
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GO:0071803
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positive regulation of podosome assembly
|
|
Cellular Component |
|
PDB ID |
MGI:96557
|
InterPro |
IPR000186
Interleukin-5
IPR009079
Four-helical cytokine-like, core
|
PFAM |
PF02025
|
PRINTS |
PR00432
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PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P04401
|
PhosphoSite |
PhosphoSite-
|
TrEMBL |
Q5SV01
|
UniProt Splice Variant |
|
Entrez Gene |
16191
|
UniGene |
Mm.4461
|
RefSeq |
NP_034688
|
MGI ID |
3B5K
|
MGI Symbol |
Il5
|
OMIM |
|
CCDS |
CCDS24685
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HPRD |
|
IMGT |
|
EMBL |
BC125366
BC132066
CH466575
X04601
X06270
X06271
|
GenPept |
AAI25367
AAI32067
CAA28266
CAA29606
CAA29607
EDL33573
|
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