Version 5.4
| Mus musculus Gene: Il5 | |||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||
| InnateDB Gene | IDBG-172199.6 | ||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
| Gene Symbol | Il5 | ||||||||||||||||||||||||||
| Gene Name | interleukin 5 | ||||||||||||||||||||||||||
| Synonyms | Il-5 | ||||||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000036117 | ||||||||||||||||||||||||||
| Encoded Proteins |
interleukin 5
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||||||||||
| Summary |
Chitin induces IL25, IL33, and TSLP which are required to stimulate ILC2 production of IL5 and IL13. IL5 and IL13, in turn, are required for the accumulation of eosinophils and alternatively activated macrophages that are associated with allergy.
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| Entrez Gene | |||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113525:
The protein encoded by this gene is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. This cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of this cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. This cytokine, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2008] This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013] |
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| Gene Information | |||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||
| Genomic Location | Chromosome 11:53720794-53725106 | ||||||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||||||
| Band | B1.3 | ||||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||
| REACTOME |
GPCR downstream signaling pathway
Hemostasis pathway
Signaling by GPCR pathway
Interleukin-2 signaling pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
GPVI-mediated activation cascade pathway
Interleukin receptor SHC signaling pathway
Signaling by Interleukins pathway
G-protein beta:gamma signalling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Signal Transduction pathway
G beta:gamma signalling through PI3Kgamma pathway
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| KEGG |
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
Hematopoietic cell lineage pathway
T cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Asthma pathway
Allograft rejection pathway
Autoimmune thyroid disease pathway
Intestinal immune network for IgA production pathway
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| INOH |
JAK STAT pathway and regulation pathway
IL-5 signaling pathway
GPCR signaling pathway
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| PID NCI | |||||||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||
| NETPATH |
IL5 pathway
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| REACTOME |
Interleukin receptor SHC signaling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Interleukin-2 signaling pathway
GPVI-mediated activation cascade pathway
G beta:gamma signalling through PI3Kgamma pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
G-protein beta:gamma signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Immune System pathway
Signaling by Interleukins pathway
Hemostasis pathway
Signaling by GPCR pathway
Interleukin-2 signaling pathway
Cytokine Signaling in Immune system pathway
Hemostasis pathway
Immune System pathway
Interleukin receptor SHC signaling pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
GPVI-mediated activation cascade pathway
GPCR downstream signaling pathway
G-protein beta:gamma signalling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Signaling by Interleukins pathway
G beta:gamma signalling through PI3Kgamma pathway
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| KEGG |
Hematopoietic cell lineage pathway
Fc epsilon RI signaling pathway pathway
Cytokine-cytokine receptor interaction pathway
T cell receptor signaling pathway pathway
Jak-STAT signaling pathway pathway
Allograft rejection pathway
Autoimmune thyroid disease pathway
Asthma pathway
Intestinal immune network for IgA production pathway
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| INOH |
JAK STAT pathway and regulation pathway
IL-5 signaling pathway
GPCR signaling pathway
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| PID NCI |
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
AP-1 transcription factor network
Glucocorticoid receptor regulatory network
IL4-mediated signaling events
Regulation of nuclear SMAD2/3 signaling
IL5-mediated signaling events
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| Cross-References | |||||||||||||||||||||||||||
| SwissProt | P04401 | ||||||||||||||||||||||||||
| TrEMBL | Q5SV01 | ||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||
| Entrez Gene | 16191 | ||||||||||||||||||||||||||
| UniGene | Mm.4461 | ||||||||||||||||||||||||||
| RefSeq | NM_010558 | ||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||
| CCDS | CCDS24685 | ||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||
| MGI ID | MGI:96557 | ||||||||||||||||||||||||||
| MGI Symbol | Il5 | ||||||||||||||||||||||||||
| EMBL | BC125366 BC132066 CH466575 X04601 X06270 X06271 | ||||||||||||||||||||||||||
| GenPept | AAI25367 AAI32067 CAA28266 CAA29606 CAA29607 EDL33573 | ||||||||||||||||||||||||||
| RNA Seq Atlas | 16191 | ||||||||||||||||||||||||||