InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hcn4

Summary

InnateDB Protein

IDBP-172258.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hcn4

Protein Name

hyperpolarization-activated, cyclic nucleotide-gated K+ 4

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034889

InnateDB Gene

IDBG-172256 (Hcn4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005222	intracellular cAMP activated cation channel activity
GO:0005248	voltage-gated sodium channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0001701	in utero embryonic development
GO:0002027	regulation of heart rate
GO:0006811	ion transport
GO:0006812	cation transport
GO:0008016	regulation of heart contraction
GO:0035725	sodium ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0055085	transmembrane transport
GO:0071320	cellular response to cAMP
GO:0071321	cellular response to cGMP
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0031226	intrinsic component of plasma membrane
GO:0043195	terminal bouton

Protein Structure and Domains

PDB ID

MGI:1298209

InterPro

IPR000595 Cyclic nucleotide-binding domain
IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
IPR005821 Ion transport domain
IPR013621 Ion transport N-terminal
IPR018490 Cyclic nucleotide-binding-like

PFAM

PF00027
PF00520
PF08412

PRINTS

PR01463

PIRSF

SMART

SM00100

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt