InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hcn4

Summary

InnateDB Gene

IDBG-172256.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hcn4

Gene Name

hyperpolarization-activated, cyclic nucleotide-gated K+ 4

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032338

Encoded Proteins

IDBP-172258

hyperpolarization-activated, cyclic nucleotide-gated K+ 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138622:
This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:58823512-58860955

Strand

Forward strand

Band

Transcripts

ENSMUST00000034889

ENSMUSP00000034889

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005222	intracellular cAMP activated cation channel activity
GO:0005248	voltage-gated sodium channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0001701	in utero embryonic development
GO:0002027	regulation of heart rate
GO:0006811	ion transport
GO:0006812	cation transport
GO:0008016	regulation of heart contraction
GO:0035725	sodium ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0055085	transmembrane transport
GO:0071320	cellular response to cAMP
GO:0071321	cellular response to cGMP
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0031226	intrinsic component of plasma membrane
GO:0043195	terminal bouton

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000138622

View Gene Order

ENSBTAG00000017466

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_13685

Neuronal System pathway

REACT_75862

HCN channels pathway

REACT_75908

Potassium Channels pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

B2RY58

UniProt Splice Variant

Entrez Gene

330953

UniGene

Mm.151967

RefSeq

NM_001081192

OMIM

CCDS

CCDS52815

HPRD

IMGT

MGI ID

MGI:1298209

MGI Symbol

Hcn4

EMBL

AC110530 BC158106 BC158108 CH466522

GenPept

AAI58107 AAI58109 EDL25959

RNA Seq Atlas

330953