InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Thbs4

Summary

InnateDB Protein

IDBP-172330.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Thbs4

Protein Name

thrombospondin 4

Synonyms

TSP4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022213

InnateDB Gene

IDBG-172328 (Thbs4)

Protein Structure

UniProt Annotation

Function

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner. {ECO:0000269PubMed:20884877, ECO:0000269PubMed:22034490, ECO:0000269PubMed:22362893, ECO:0000269PubMed:22682248, ECO:0000269PubMed:22745497, ECO:0000269PubMed:23615612}.

Subcellular Localization

Endoplasmic reticulum. Sarcoplasmic reticulum. Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix.

Disease Associations

Tissue Specificity

Heart. Up-regulated in the heart in response to ischemic injury and pathology (at protein level). Astrocytes; expressed at high levels in subventricular zone (SVZ)-derived astrocytes and at low levels in cortical astrocytes. In response to peripheral nerve injury, significantly up-regulated in the dorsal spinal cord (at protein level). {ECO:0000269PubMed:22362893, ECO:0000269PubMed:22745497, ECO:0000269PubMed:23615612}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0008201	heparin binding

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0006986	response to unfolded protein
GO:0007155	cell adhesion
GO:0016525	negative regulation of angiogenesis
GO:0034103	regulation of tissue remodeling
GO:0034976	response to endoplasmic reticulum stress
GO:0048266	behavioral response to pain
GO:0048771	tissue remodeling
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0051451	myoblast migration
GO:0051781	positive regulation of cell division
GO:0071603	endothelial cell-cell adhesion
GO:0090023	positive regulation of neutrophil chemotaxis

Cellular Component

GO:0005576	extracellular region
GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0005783	endoplasmic reticulum
GO:0016529	sarcoplasmic reticulum
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

MGI:1101779

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001791 Laminin G domain
IPR001881 EGF-like calcium-binding domain
IPR003367 Thrombospondin, type 3-like repeat
IPR008859 Thrombospondin, C-terminal
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR024665 Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain
IPR028974 TSP type-3 repeat

PFAM