InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Arl6ip5

Summary

InnateDB Protein

IDBP-172336.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arl6ip5

Protein Name

ADP-ribosylation factor-like 6 interacting protein 5

Synonyms

5930404D22Rik; addiscin; Aip-5; AV001879; Gtrap3-18;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000041503

InnateDB Gene

IDBG-172334 (Arl6ip5)

Protein Structure

UniProt Annotation

Function

Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate. May be involved in membrane traffic. {ECO:0000269PubMed:12119102}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:12438930}; Multi-pass membrane protein {ECO:0000269PubMed:12438930}. Cytoplasm {ECO:0000269PubMed:12438930}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:12438930}. Note=Also exists as a soluble form in the cytoplasm. Associated with microtubules.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:12119102, ECO:0000269PubMed:12438930}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding

Biological Process

GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0010917	negative regulation of mitochondrial membrane potential
GO:0015813	L-glutamate transport
GO:0032874	positive regulation of stress-activated MAPK cascade
GO:0043065	positive regulation of apoptotic process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0051051	negative regulation of transport

Cellular Component

GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005856	cytoskeleton
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome