Version 5.4
Mus musculus Gene: Arl6ip5
Summary
InnateDB Gene IDBG-172334.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arl6ip5
Gene Name ADP-ribosylation factor-like 6 interacting protein 5
Synonyms 5930404D22Rik; addiscin; Aip-5; AV001879; Gtrap3-18
Species Mus musculus
Ensembl Gene ENSMUSG00000035199
Encoded Proteins
IDBP-172336
ADP-ribosylation factor-like 6 interacting protein 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000144746:
Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:97210689-97233315
Strand Forward strand
Band D3
Transcripts
ENSMUST00000044681 ENSMUSP00000041503
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
Biological Process
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0010917 negative regulation of mitochondrial membrane potential
GO:0015813 L-glutamate transport
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0043065 positive regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0051051 negative regulation of transport
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005856 cytoskeleton
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000144746
View Gene Order
ENSBTAG00000021506
Not yet available
Cross-References
SwissProt Q8R5J9
TrEMBL
UniProt Splice Variant
Entrez Gene 65106
UniGene Mm.291014
RefSeq NM_022992
OMIM
CCDS CCDS20384
HPRD
IMGT
MGI ID MGI:1929501
MGI Symbol Arl6ip5
EMBL AF133912 AF265214 AF421860 AK005259 AK008519 AK076519 AK088205 BC003897 D87211
GenPept AAD33050 AAH03897 AAL74056 AAL77876 BAB23912 BAB25717 BAC24103 BAC36376 BAC40209
RNA Seq Atlas 65106

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca