InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc22a5

Summary

InnateDB Protein

IDBP-172350.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc22a5

Protein Name

solute carrier family 22 (organic cation transporter), member 5

Synonyms

jvs; Lstpl; Octn2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000019044

InnateDB Gene

IDBG-172348 (Slc22a5)

Protein Structure

UniProt Annotation

Function

Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.

Subcellular Localization

Apical cell membrane {ECO:0000269PubMed:15523054}; Multi-pass membrane protein {ECO:0000269PubMed:15523054}. Note=Colocalizes with PDZK1 on apical membranes of kidney proximal tubules.

Disease Associations

Note=Defects in Slc22a5 are the cause of the juvenile visceral steatosis (JVS) phenotype. JVS is an autosomal recessive animal model of systemic carnitine deficiency.

Tissue Specificity

Widely expressed. Expressed in kidney, liver and testis. {ECO:0000269PubMed:11010964}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0015075	ion transmembrane transporter activity
GO:0015226	carnitine transmembrane transporter activity
GO:0015293	symporter activity
GO:0015651	quaternary ammonium group transmembrane transporter activity
GO:0022857	transmembrane transporter activity

Biological Process

GO:0006814	sodium ion transport
GO:0007005	mitochondrion organization
GO:0007512	adult heart development
GO:0007626	locomotory behavior
GO:0009437	carnitine metabolic process
GO:0015697	quaternary ammonium group transport
GO:0015879	carnitine transport
GO:0034220	ion transmembrane transport
GO:0048608	reproductive structure development
GO:0055085	transmembrane transport
GO:1902603	carnitine transmembrane transport

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0031526	brush border membrane

Protein Structure and Domains

PDB ID

MGI:1329012

InterPro

IPR004749 Organic cation transport protein
IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF00083
PF07690

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Z0E8

PhosphoSite