InnateDB Protein
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IDBP-172384.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Pkp4
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Protein Name
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plakophilin 4
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000099815
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InnateDB Gene
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IDBG-172382 (Pkp4)
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Protein Structure
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Function |
Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cell junction, desmosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Midbody {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Associated with the pericentrosomal region in interphase and with spindle poles during mitosis. In anaphase, during chromosome segregation, is recruited to the central microtubule bundle, focussed at the spindle midzone and ultimately localizes to the midbody at cytokinesis. Constituent of the midbody cytoskeletal matrix. Colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
19 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:109281
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InterPro |
IPR000225
Armadillo
IPR016024
Armadillo-type fold
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PFAM |
PF00514
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PRINTS |
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PIRSF |
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SMART |
SM00185
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TIGRFAMs |
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Modification |
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SwissProt |
Q68FH0
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PhosphoSite |
PhosphoSite-Q68FH0
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TrEMBL |
A2AS47
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UniProt Splice Variant |
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Entrez Gene |
227937
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UniGene |
Mm.486344
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RefSeq |
NP_080637
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MGI ID |
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MGI Symbol |
Pkp4
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OMIM |
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CCDS |
CCDS16052
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HPRD |
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IMGT |
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EMBL |
AK021168
AK077250
AK078240
AL845536
BC078638
BC079848
BC082578
BX649232
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GenPept |
AAH78638
AAH79848
AAH82578
BAB32313
BAC36708
BAC37187
CAM20481
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